Trajenta® (Linagliptin) Tablets

What Is Trajenta®?

Trajenta® contains linagliptin, a DPP-4 inhibitor that enhances the body’s natural incretin hormones. These hormones play an important role in regulating blood sugar levels following meals.

In line with guidance from the National Institute for Health and Care Excellence (NICE), DPP-4 inhibitors may be considered when metformin alone is insufficient or unsuitable. Trajenta® may be prescribed on its own or in combination with other glucose-lowering medicines such as metformin.

How Trajenta® Works

Linagliptin works by blocking the DPP-4 enzyme responsible for breaking down incretin hormones (GLP-1 and GIP). By prolonging their activity, Trajenta®:

• Stimulates insulin release in response to elevated blood glucose levels
• Reduces glucagon secretion
• Decreases glucose production in the liver

These effects contribute to improved postprandial and overall glycaemic control without typically causing significant weight gain.

Dosage and Administration

Route of administration: Oral.

Trajenta® is usually taken once daily, with or without food. The tablet should be swallowed whole with water.

Consistent daily use alongside a balanced diet and regular physical activity supports optimal diabetes management. Always follow your healthcare professional’s instructions regarding dosage and monitoring.

Common Side Effects

• Nasopharyngitis (nasal congestion or cold-like symptoms)
• Cough
• Diarrhoea
• Headache

Serious but Uncommon Reactions

• Severe allergic reactions: Rash, swelling, breathing difficulties
• Pancreatitis: Persistent, severe abdominal pain
• Severe joint pain

Seek immediate medical advice if any serious symptoms occur.

Drug Interactions

Trajenta® may interact with other antidiabetic medicines.

• Insulin or sulfonylureas: May increase the risk of hypoglycaemia.

Inform your healthcare provider about all medicines, supplements and over-the-counter products you are taking.

Precautions and Contraindications

• History of pancreatitis
• Severe renal or hepatic impairment
• Previous hypersensitivity reactions to linagliptin

Trajenta® is not indicated for the treatment of type 1 diabetes or diabetic ketoacidosis.

Storage Instructions

Store tablets at room temperature, protected from moisture and excessive heat. Keep in the original packaging and out of sight and reach of children.

Buying Trajenta® Online

Trajenta® is a prescription-only medicine. When purchasing online, ensure the pharmacy is appropriately regulated and requires a valid prescription.

You may browse our type 2 diabetes medication category for related treatment options.

For full prescribing information, consult the official product monograph: Trajenta® Product Monograph.